Bombesin, Trypsin, and Chronic Pancreatitis

Chronic pancreatitis resulting from genetic mutations in trypsin and trypsin inhibitors.

pancreatitis, and chronic pancreatitis

EDITORIAL SYNOPSIS Two hundred and five confirmed cases of pancreatitis have been classified. Primary calcifying pancreatitis is associated with alcoholism. Pancreatic changes are patchy and related to plugging of minute ducts. Cysts are frequent. Obstruction to the main pancreatic duct may also result in chronic pancreatitis. Acute pancreatitis and acute recurrent pancreatitis are often associ...

The Role of Trypsin and Bile Acids in Acute and Chronic Pancreatitis

From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene.

Pancreatic secretory trypsin inhibitor (PSTI) is a potent natural inhibitor of trypsin. We proposed the hypothesis that, if the function of the PSTI is impaired by its genetic mutation, trypsin may easily promote autodigestion causing pancreatitis and we performed a mutational analysis of the PSTI gene in patients with pancreatitis. Two exonic mutations (N34S and R67C) were thought to be associ...

Trypsin secretion and turnover in patients with acute pancreatitis.

Studies in humans have shown that pancreatic enzyme secretion is reduced during acute pancreatitis. It is not known, however, whether the reduction is due to impaired synthesis or disruption of the secretory pathway. The rate of secretion and turnover of trypsin was measured in 12 patients with acute pancreatitis of variable etiology and severity (median Ranson's score 2.5, range 0-5, 4 with se...